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Traditional versus nontraditional risk factors and incidence of adult overweight and obesity in the Quebec Family Study. Recent analyses of the data from QFS also allowed establishing some links with relevant biomarkers.

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Model adjusted for age, sex, baseline body mass index, length of follow-up, and socioeconomic status. J Clin Invest ; Progress in obesity research: This is bouchafd learning or a practical skill that is mandatory before enrolment in this module is allowed.

Because of its extensive panel of behavioral and lifestyle measurements, QFS has become an important resource in boouchard search for gene-behavior interaction effects on obesity-related traits.

Experimental sleep restriction has been reported to increase appetite via an up-regulation of appetite-stimulating hormones [ 61 ]. Chair in Genetics and Nutrition.

It was perceived as a good compromise between the burden imposed to the participants and the ability to obtain information on food habits under free-living conditions. Incompatible Modules These are modules which have learning outcomes that are too similar to the learning outcomes of this module. Associate Member in Physics on sabbatical — Thomas E.

Introduction The main goal of the Quebec Family Study QFS as originally planned was to investigate the role 8060 genetic factors in physical fitness, body composition, risk factors for common diseases and health related behavior. These are modules which have learning outcomes that are too similar to the learning outcomes of this module.

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Disinhibition as an eating behavior trait reflects a tendency toward overeating and eating opportunistically and is assessed in QFS using the Three-Factor Eating Questionnaire developed by Stunkard and Messick [ 69 ]. There is no repeat written examination.

The first QFS papers pertaining to the genetics of obesity were published in the early s and have shown significant familial resemblance for boucyard phenotypes of obesity. Impact of dietary fat content and fat oxidation on energy intake in humans.

Engage in and critically analyse a physical biuchard intervention that involves assessment of fundamental movement skills, anthropometric measurements and physical fitness of children.

A similar pattern was observed for weight gain over a 6-year follow-up period.

In the presence of such a major gene effect, the distribution of the phenotype is represented by a mixture of distributions consistent with the segregation of three genotypes instead of the normal boucharc associated with a polygenic effect.

Boucgard, Daniel Dufort, Teruko Taketo. More recently, a genome-wide association study GWAS was performed on the QFS cohort using the Illumina Quad chip containing more thansingle-nucleotide polymorphisms SNPs that were tested for association with various obesity-related phenotypes [ 33 ].

These analyses showed a significant positive association bouhcard fat mass or subcutaneous adiposity and percent energy intake as lipid. Interestingly, preliminary findings from QFS lend support to the concept that increasing sleeping time in short-duration sleepers has the potential to limit adiposity gain over time [ 68 ].

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Data of this cohort were used extensively to examine the relationship between body fatness and habitual dietary fat intake. In summary, we were able to evidence the contribution of a number of candidate genes to human variation in adiposity phenotypes and other obesity-related traits including eating behavior traits. Guelph David Dankort; B. In summary, QFS has contributed significantly over the last three decades to our understanding of the etiology of obesity. Table adapted from Chaput et al.

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The gene most likely responsible for the evidence of linkage the gene closest to the linkage peak is also indicated in the table. Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q.

J Clin Epidemiol ; The key limitations of QFS need to be highlighted in order to put these observations into perspective.

Significant familial aggregation and heritability level were observed not only for BMI, total adiposity, fat-free mass, subcutaneous fat boucnard, abdominal fat and visceral adipose tissue level but also for metabolic rates, physical activity level, macronutrient intake and eating behavior traits. A novel interaction between dietary composition and insulin secretion: National Center for Biotechnology InformationU.

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Familial resemblance in eating behaviors in men and women from the Quebec Family Study. Conflict houchard Interest Jean-Philippe Chaput declares that he has no conflict of interest.

A separate study suggested that this potential effect of exercise intensity might be partly explained by an increase in post-exercise resting metabolic rate [ 43 ].