Two types of diabetes are usually seen in patients with cirrhosis: type 2 diabetes mellitus and hepatogenous diabetes (HD). The HD is an. Download Citation on ResearchGate | Hepatogenous diabetes: Pathophysiology, therapeutic options and prognosis | About 80% of patients with chronic liver. A literature search was conducted in different databases to study the topic of liver problems and diabetes. The aim of the study was to explore more about an.

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Madero y Gonzalitos, Col. In addition, the described differences between hereditary type 2 DM and HD regarding pathophysiology, risk factors, clinical features, effects on outcome and therapeutic results diabetws strong reasons for diagnosing them as separated entities.

A recent study by Hodson et al. The prevalence and clinical characteristics of glucose metabolism disorders in patients with liver cirrhosis.

HD in early cirrhosis stages may be sub clinical. J Gastroenterol Hepatol ; An underestimated problem of liver cirrhosis. This paper will review current concepts in relation to the pathopysiology, the impact on the clinical outcome of cirrhosis, and the therapy of HD.

Hepatogenous diabetes. Current views of an ancient problem.

Systematic review and meta-analysis. Effect heaptogenous physiologic hyperinsulinemia on glucose and lipid metabolism in cirrhosis. This review article provides an overview of magnitude, patients’ characteristics, clinical implications, pathophysiological mechanisms, diagnosis, and management of HD.


Its use did not extend, probably because the concept was then misunderstood. Clinical pharmacokinetics of sulphonylurea hypoglycaemic drugs. A key player in chronic liver disease. The mechanism by which HD may deteriorate liver function giving rise to adverse outcomes is not precisely known.

Diabetes mellitus at the time of diagnosis of cirrhosis is associated diabeges higher incidence of spontaneous bacterial peritonitis, but not with increased mortality. Abnormal tissue oxygenation in patients with cirrhosis and hfpatogenous failure.

This may be explained because of presumptive acceleration of liver failure induced by HD probably shortens the time in which diabetic cardiovascular complications can take place.

We have discussed some liver alterations caused by diabetes, or some liver problems prevalent in diabetic patients. Insulin resistance and HD associate to a decrease in the sustained response to antiviral therapy and an increased progression of fibrosis in patients with CHC.

Dig Dis Sci ; Vlassara H, Uribarri J. J Clin Endocrinol Metab. The hepatogenous diabetes differ from lifestyle-related type 2 diabetes in its pathogenesis, cause of death, assessment, and therapeutic strategy [ 18 ].


Influence of renal or hepatic impairment on hepatogsnous pharmacokinetics of saxagliptin. The pancreatic damage leads to diabetes and that eventually leads to liver problems like fatty liver eventually leading to cirrhosis. HD is also associated with increased rate of liver complications such as duabetes encephalopathy, esophageal variceal hemorrhage, spontaneous primary peritonitis and renal impairment[ 27 – 30 ]. Diabetes increases the risk of acute hepatic failure. Pharmacokinetics of insulin aspart in obesity, renal impairment, or hepatic impairment.

The American Diabetes Association do not yet recognize Hepatogneous Diabetes [ 39 ], and no treatment has been proposed officially for the problem.

Hepatogenous diabetes. Current views of an ancient problem.

In this mini review, we will highlight the topic about the association of liver diseases with diabetes mellitus. Perisinusoidal fibrosis is also common in the liver of type I diabetic patients. The study suggested that Hepatitis C virus may have direct role in development of diabetes [ diabehes ]. Clin Sci Lond ; Microvascular complications include Diabetic retinopathyDiabetic nephropathy and Diabetic neuropathy.